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Yiqing Song MD, ScD

Professor & PhD Program Director, Epidemiology

Dr. Yiqing Song is an Associate Professor in the IU Richard M. Fairbanks School of Public Health and Director of the PhD program in Epidemiology.  Dr. Song received a Medical degree from Beijing Medical University and finished his residency training in Pediatrics at the Third Teaching Hospital of Beijing Medical University.  Between 1998 and 2004, he received a Master degree in Nutrition from the University of Texas at Austin and a Doctor of Science (ScD) degree in Epidemiology and Nutrition from Harvard School of Public Health.  Dr. Song was faculty in the Division of Preventive Medicine at Brigham and Women’s Hospital, Harvard Medical School, between 2005 and 2013.

Dr. Song’s primary research area is the primary prevention and epidemiology of type 2 diabetes and cardiovascular disease. He has led many epidemiological studies in large-scale prospective cohorts such as the Women’s Health Study (WHS), the Women's Antioxidant Cardiovascular Study (WACS), the Physicians’ Health Study (PHS), and the Women’s Health Initiative Observational Study (WHI-OS). His major research interests include: 1) nutritional factors for risk of type 2 diabetes and cardiovascular disease, with focus on trace elements and antioxidants, such as magnesium, vitamin C, E, D and beta-carotene; 2) novel biochemical and genetic biomarkers for predicting risk of type 2 diabetes, such as sex-steroid hormones and adipokines; 3) complex interactions among nutrition, biomarkers, and genetic factors in cardiometabolic disease; and 4) design, methodology, and conduct of conventional and Bayesian-based meta-analysis for synthesizing evidence from case-control studies, cohort studies, and randomized trials.

Dr. Song has been the PI and Co-PI on a number of NIH-funded grants. Currently, Dr. Song is the PI of a NHLBI-supported R01 grant to conduct a comprehensive evaluation of the full spectrum of variation in biomarkers of vitamin D/parathyroid hormone (PTH) endocrine system and to examine their potential contributions to racial/ethnic disparities in CVD risk in the WHI-OS. He also serves as the PI of a diabetes prevention trial to test whether vitamin D and omega-3 supplementation will reduce the risk of type 2 diabetes in the VITamin D and OmegA-3 TriaL (VITAL), a trial that evaluates the balance of benefits and risks of vitamin D3 (2,000 IU/day) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], 840mg/day) supplements in primary prevention of cardiovascular disease and cancer among 20,000 U.S. men and women. Dr. Song also leads another VITAL ancillary study to test the hypothesis that magnesium status interacts with vitamin D treatment to affect type 2 diabetes and CVD risk as well as longitudinal change in intermediate cardiometabolic phenotypes.  

Dr. Song has authored and co-authored more than 90 peer-reviewed research papers and 8 book chapters. He is currently editorial board members of PLoS One and the International Journal of Molecular Epidemiology and Genetics. He has served as ad hoc reviewer for a number of International and National Foundation/Society funding agencies and over 30 peer-reviewed scientific journals. 

Ten select publications (from over 93 original articles)

Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295(11):1288-99.

Zhang J, Ding EL, Song Y. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA. 2006;296(13):1619-32.

Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S. Circulating levels of endothelial adhesion molecules and risk of diabetes mellitus in an ethnically diverse cohort of women. Diabetes. 2007;56:1898-904.

Song Y, Manson JE, Tinker L, Howard B, Kuller L, Nathan L, Rifai N, Liu S. Insulin sensitivity and insulin secretion determined by the Homeostasis Model Assessment (HOMA) and risk of diabetes mellitus in a multi-ethnic cohort of women: the Women’s Health Initiative Observational Study. Diabetes Care. 2007;30(7):1747-52.

Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE. Effect of homocysteine-lowering treatement with folic acid and B vitamins on risk of type 2 diabetes mellitus in women: a randomized controlled trial. Diabetes. 2009;58:1921-8.

Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE. Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes mellitus among women at high risk for cardiovascular disease: a randomized controlled trial. Am J Clin Nutr. 2009;90:429-37.

Ding EL, Song Y*, Manson JE, Hunter DJ, Lee CC, Rifai N, Buring JE, Gaziano JM, Liu S. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med. 2009; 361(12):1152-63 (*co-first author).

Song Y, Manson JE, Lee I-M, Cook NR, Paul L, Selhub J, Giovannucci E, Zhang S. Effect of combined folic acid, vitamin B6, and vitamin B12 on colorectal adenoma. J Natl Cancer Inst. 2012;104(20):1562-75.

Song Y, Yeung E, Liu A, Vanderweele TJ, Chen L, Lu C, Liu C, Schisterman EF, Ning Y, Zhang C. Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. Hum Mol Genet. 2012;21(22):5010-8.

Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, Hu FB. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013;36(5):1422-8.

Yiqing Song MD, ScD
  • Yiqing Song MD, ScD